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4-Hydroxy-2-(trifluoromethyl)benzoic acid (CAS number 320-32-1) has hydroxyl, carboxylic acid and trifluoromethyl functional groups on the benzene ring. The carboxylic acid and hydroxyl groups are in the para-position, enabling it to synthesis linear molecules. Polyesters with segments of 4-hydroxy-2-(trifluoromethyl)benzoic acid self-assemble to form spherulite crystals for the fabrication of optical vortex beam generator. 4-Hydroxy-2-(trifluoromethyl)benzoic acid reacts with alkylated acyl chloride for the synthesis of smectic C liquid crystals.

Additionally, 4-hydroxy-2-(trifluoromethyl)benzoic acid can be attached to molecular scaffolds, such as benzofuran derivatives, through esterification and amide synthesis for producing active pharmaceutical ingredients (APIs) as antitubercular agents.

General Information


CAS Number 320-32-1
Chemical Formula C8H5F3O3
Full Name 4-Hydroxy-2-(trifluoromethyl)benzoic acid
Molecular Weight 206.12 g/mol
Synonyms α,α,α-Trifluoro-4-hydroxy-o-toluic acid, 4-Carboxy-3-(trifluoromethyl)phenol
Classification / Family Fluorinated building blocks, Benzoic acid building blocks, Phenol building blocks, Heterocycles, Liquid crystals, APIs

Chemical Structure


4-Hydroxy-2-(trifluoromethyl)benzoic acid chemical structure, CAS 320-32-1.
4-Hydroxy-2-(trifluoromethyl)benzoic acid chemical structure, CAS 320-32-1

Product Details


Purity 98%
Melting Point Tm = 159 °C – 161 °C
Appearance White powder


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