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4-Bromo-2,6-difluoroaniline (CAS number 67567-26-4) is an aniline derivative with a bromine at para-position and two fluorines at ortho-positions. The multiple substituents have different chemical reactivities, making 4-bromo-2,6-difluoroaniline a versatile building block in chemical synthesis. The bromo-substituent allows Pd-catalyzed coupling reaction for expanding the size of the molecule. The amine group is used as a nucleophile in a chemical reaction, or it can also be oxidized to amine oxide to synthesize conjugated azo compounds. The fluoro-substitutes adjust the energy level of the molecular orbitals while they can undergo nucleophilic aromatic substitution for designing macromolecules.
A Pd-azobenzene complex based on 4-bromo-2,6-difluoroaniline has shown photo-switching properties. It can reversibly switch to two discrete self-assembled structures. A conjugated quasiplanar triarylamines synthesized from 4-bromo-2,6-difluoroaniline is used as hole-transporting material in perovskite solar cells and OLEDs.
General Information
| CAS Number | 67567-26-4 |
| Chemical Formula | C6H4F2NBr |
| Full Name | 4-Bromo-2,6-difluoroaniline |
| Molecular Weight | 208.01 g/mol |
| Synonyms | 4-Bromo-2,6-difluorobenzenamine |
| Classification / Family | Fluorinated building block, Amine building block, Azo-dyes, solar cells, OLEDs, semiconductors, macromolecules |
Chemical Structure

Product Details
| Purity | 98% |
| Melting Point | Tm = 63 – 65 °C |
| Appearance | White powder |


