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4-Fluoro-4′-methoxybenzophenone (CAS number 345-89-1) is a benzophenone building block with fluorine and methoxy groups on both para-positions. Benzophenone derivatives are photosensitive, thus, 4-fluoro-4′-methoxybenzophenone is applied as a photocatalyst for photochemical fluorination with sulfur hexafluoride as the fluorine source. The photocatalytic reaction is performed under a 365 nm UV radiation, resulting in a moderated 56% yield.
4-Fluoro-4′-methoxybenzophenone is also utilized in the preparation of fluorenone, a fluorene derivative with a ketone on the 9-position. Fluorenone finds widespread applications in pharmaceutical industry and organic electronics. The reaction involves a palladium-catalyzed dehydrogenative cyclization, yielding up to 90%.
General Information
| CAS Number | 345-89-1 |
| Chemical Formula | C14H11FO2 |
| Full Name | (4-Fluorophenyl)(4-methoxyphenyl)methanone |
| Molecular Weight | 230.23 g/mol |
| Synonyms | N/A |
| Classification / Family | Fluorinated building blocks, Benzophenone building blocks, Fluorenes, Polyketone esters, Photocatalysts |
Chemical Structure

Product Details
| Purity | 98% |
| Melting Point | Tm = 96 °C |
| Appearance | White crystals |


