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4-Hydroxy-2-(trifluoromethyl)benzoic acid (CAS number 320-32-1) has hydroxyl, carboxylic acid and trifluoromethyl functional groups on the benzene ring. The carboxylic acid and hydroxyl groups are in the para-position, enabling it to synthesis linear molecules. Polyesters with segments of 4-hydroxy-2-(trifluoromethyl)benzoic acid self-assemble to form spherulite crystals for the fabrication of optical vortex beam generator. 4-Hydroxy-2-(trifluoromethyl)benzoic acid reacts with alkylated acyl chloride for the synthesis of smectic C liquid crystals.
Additionally, 4-hydroxy-2-(trifluoromethyl)benzoic acid can be attached to molecular scaffolds, such as benzofuran derivatives, through esterification and amide synthesis for producing active pharmaceutical ingredients (APIs) as antitubercular agents.
General Information
| CAS Number | 320-32-1 |
| Chemical Formula | C8H5F3O3 |
| Full Name | 4-Hydroxy-2-(trifluoromethyl)benzoic acid |
| Molecular Weight | 206.12 g/mol |
| Synonyms | α,α,α-Trifluoro-4-hydroxy-o-toluic acid, 4-Carboxy-3-(trifluoromethyl)phenol |
| Classification / Family | Fluorinated building blocks, Benzoic acid building blocks, Phenol building blocks, Heterocycles, Liquid crystals, APIs |
Chemical Structure

Product Details
| Purity | 98% |
| Melting Point | Tm = 159 °C – 161 °C |
| Appearance | White powder |
