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3′-Fluoro-4′-methoxyacetophenone (CAS number 455-91-4) is an acetophenone derivative with a fluorine and a methoxy substituents. 3′-Fluoro-4′-methoxyacetophenone is used to prepare chalcone derivatives with benzaldehydes by aldol condensation. Chalcones are α,β-unsaturated ketones employed as active pharmaceutical ingredients (APIs) and fluorescent dyes. Pyrazole derivatives such as celecoxib, an anti-inflammatory drug, are obtained from chalcones reacting with hydrazine derivatives. Chalcone derivatives can be further functionalized to produce epoxides via Juliá–Colonna epoxidation.
3′-Fluoro-4′-methoxyacetophenone is also a key component in Mannich reaction along with formaldehyde and secondary amines, for β-amino-carbonyl compounds, also known as Mannich bases.
General Information
| CAS Number | 455-91-4 |
| Chemical Formula | C9H9FO2 |
| Full Name | 1-(3-fluoro-4-methoxyphenyl)ethan-1-one |
| Molecular Weight | 168.17 g/mol |
| Synonyms | 1-(3-Fluoro-4-methoxyphenyl)-1-ethanone |
| Classification / Family | Fluorinated building blocks, Acetophenone building blocks, Heterocycles, APIs |
Chemical Structure

Product Details
| Purity | 98% |
| Melting Point | Tm = 92 °C – 94 °C |
| Appearance | Off-white powder |


