产品名称：3 - 氟 - 2 - 吡啶甲腈

3-Fluoro-2-pyridinecarbonitrile (CAS number 97509-75-6) is a pyridine derivative having a fluorine and a nitrile group at 3- and 2-positions. 3-Fluoro-2-pyridinecarbonitrile can undergo different reactions, such as nucleophilic aromatic substitutions on the fluorine substituted carbon. It allows 3-fluoro-2-pyridinecarbonitrile to attach to chromophores like carbazoles, for synthesizing aggregation-induced emission molecules. Such method is also applied to pharmaceutical compounds, by attaching 3-fluoro-2-pyridinecarbonitrile to negative allosteric modulator small molecules leading to an improved binding affinity to glutamate receptors for the treatment of central nervous system diseases.

3-Fluoro-2-pyridinecarbonitrile is also used to prepare tetrazine through bioorthogonal chemistry with hydrazine. The as-synthesized tetrazines facilitate additional reactions, including tetrazine ligation and [4+1] cycloaddition.

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