产品名称：2 - 氨基 - 3 - 氟吡啶

2-Amino-3-fluoropyridine (CAS number 21717-95-3) is derived from pyridine having an amine and a fluorine at 2- and 3-positions. 2-Amino-3-fluoropyridine can be readily introduced to molecular scaffolds by reductive amination and nucleophilic substitution. The modification by 2-amino-3-fluoropyridine has shown a significant enhancement in antitumor activity, compared with the mother molecules. It is suggested that the 2-amino-3-fluoropyridine moiety forms a π–π interaction with the arginine residue in the protein sequence, leading to improved inhibitory.

Furthermore, 2-amino-3-fluoropyridine is also used to synthesize bicyclic heterocycles such as imidazopyridines for pharmaceutical active ingredients through Baylis-Hillman reaction.

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