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- 入驻时间： 2014-11-28
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产品详情
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产品名称：N-Boc-4,4-difluoro-L-proline
- 产品型号： 203866-15-3
- 产品厂商：Ossila
- 产品价格：0
- 折扣价格：0
- 产品文档：
MSDS n-boc-4-4-difluoro-l-proline
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简单介绍：
详情介绍：
N-Boc-4,4-difluoro-l-proline (CAS number 203866-15-3) is a tert-butoxycarbonyl (Boc) protected l-proline with two fluorine substituents at 4-position. N-Boc-4,4-difluoro-l-proline is an S-enantiomer, making it an excellent additive/catalyst in asymmetric reactions. In protein/peptide chemistry, N-Boc-4,4-difluoro-l-proline is introduced for conformational control favoring 78% cis-conformers. The conformation selectivity is also expressed in the 19F NMR spectrum which is a powerful tool to study the isomerization of peptides and proteins.
N-Boc-4,4-difluoro-l-proline is also applied as a molecular scaffold for synthesizing fibroblast activation protein, a trans-membrane serine protease.
General Information
| CAS Number | 203866-15-3 |
| Chemical Formula | C10H15F2NO4 |
| Full Name | (S)-1-(tert-Butoxycarbonyl)-4,4-difluoro-2-pyrrolidinecarboxylic acid |
| Molecular Weight | 251.23 g/mol |
| Synonyms | N-(tert-Butoxycarbonyl)-4,4-difluoro-l-proline |
| Classification / Family | Fluorinated building blocks, Heterocyclic building blocks, Proteins, Peptides, Asymmetric synthesis, Chiral molecules |
Chemical Structure
Product Details
| Purity | 97% |
| Melting Point | Tm = 120 °C – 140 °C |
| Optical Rotation | −44.19 ° (c = 1, methanol) |
| Appearance | Off-white powder |