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2,4-Difluorobenzonitrile (CAS number 3939-09-1) is a benzonitrile derivative with two fluorine atoms at 2- and 4-positions. 2,4-Difluorobenzonitrile is commonly used as a molecular building block for introducing fluorinated benzonitrile to the target molecules by nucleophilic aromatic substitution. The reactive side is primarily on the para-position to the nitrile group, as it is less sterically hindered. 2,4-Difluorobenzonitrile functionalized triazolopyrimidine has been comprehensively studied on treatment of Alzheimer's disease.
2,4-Difluorobenzonitrile reacts with sodium azide for fluorinated tetrazole, a 5-membered ring heterocyclic with four nitrogen atoms. Fluorinated phenyltetrazole forms complexes with iridium showing blue light photoluminescence quantum yield up to 76%. The complexes are promising to be used in OLEDs and photoredox catalytic reactions.
General Information
| CAS Number | 3939-09-1 |
| Chemical Formula | C7H3F2N |
| Full Name | 2,4-Difluorobenzonitrile |
| Molecular Weight | 139.10 g/mol |
| Synonyms |
N/A |
| Classification / Family | Fluorinated building block, Ligands, OLEDs, APIs, Photoredox catalysts |
Chemical Structure

Product Details
| Purity | 98% |
| Melting Point | Tm = 47 – 49 °C |
| Appearance | White to off-white solid |
