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产品名称： 2,4-Difluoro-(1H-1,2,4-triazolyl)acetophenone
- 产品型号： 86404-63-9
- 产品厂商：Ossila
- 产品价格：0
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- 产品文档：
MSDS 2-4-difluoro-1h-1-2-4-triazolylacetophenone
2,4-Difluoro-(1H-1,2,4-triazolyl)acetophenone (CAS number 86404-63-9) has a difluoroacetophenone that is attached to a triazole unit. 2,4-Difluoro-(1H-1,2,4-triazolyl)acetophenone is a molecular scaffold for triazole antifungal medications, for instance, fluconazole, voriconazole and efinaconazole. The ketone moiety in 2,4-difluoro-(1H-1,2,4-triazolyl)acetophenone allows various modifications via Grignard reaction and aldol reaction. Enantioselective additions are also sufficient with chiral prolines catalyzed aldol reaction or chiral auxiliaries assisted Grignard reaction.
With the addition of chromophores, 2,4-difluoro-(1H-1,2,4-triazolyl)acetophenone has been used to study the mechanism of antifungal activity in live Candida cells, with fluorescent microscopy.
General Information
| CAS Number | 86404-63-9 |
| Chemical Formula | C10H7F2N3O |
| Full Name | 2,4-Difluoro-(1H-1,2,4-triazolyl)acetophenone |
| Molecular Weight | 223.18 g/mol |
| Synonyms | 1-(2,4-Difluorobenzoylmethyl)-1H-1,2,4-triazole, 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone, Voriconazole Related Compound C, Fluconazole Impurity E |
| Classification / Family | Fluorinated building block, Heterocyclic building block, APIs, Bioimaging |
Chemical Structure
Product Details
| Purity | 98% |
| Melting Point | Tm = 103 – 107 °C |
| Appearance | Off-white powder |