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产品名称：3-(4 - 氟苯基)-1 - 异丙基吲哚
- 产品型号：93957-49-4
- 产品厂商：Ossila
- 产品价格：0
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- 产品文档：
MSDS 3-4-fluorophenyl-1-isopropylindole
3-(4-Fluorophenyl)-1-isopropylindole (CAS number 93957-49-4) is a derivative of indole, a heterobicyclic compound, with a 4-fluorophenyl (3-position) and an isopropyl substituent (1-position). 3-(4-Fluorophenyl)-1-isopropylindole is the nucleus of Fluvastatin, a drug used to treat hypercholesterolemia for preventing cardiovascular diseases. A series of 3-(4-Fluorophenyl)-1-isopropylindole derivatives are synthesized, presenting a significant decrease of serum total cholesterol, triglycerides, and low-density lipoprotein levels. The syntheses involve a Vilsmeier-Haack reaction for introducing an aldehyde to the 2-position and then a Claisen-Schmidt condensation for the modification of the aldehyde.
3-(4-Fluorophenyl)-1-isopropylindole also shows non-linear optical properties. The electron-withdrawing substituent of indole increases the hyperpolarizability coefficient, thus resulting a better non-linear optical response.
General Information
| CAS Number | 93957-49-4 |
| Chemical Formula | C17H16FN |
| Full Name | 3-(4-Fluorophenyl)-1-isopropyl-1H-indole |
| Molecular Weight | 253.32 g/mol |
| Synonyms | 1-Isopropyl-3-(4-fluorophenyl)indole |
| Classification / Family | Fluorinated building block, heterocyclic building block, APIs, Photonics |
Chemical Structure
Product Details
| Purity | 97% |
| Melting Point | Tm = 95 °C – 98 °C |
| Appearance | Off-white to pale beige powder |