产品名称：3-(Trifluoromethyl)-2-pyridone

3-(Trifluoromethyl)-2-pyridone (CAS number 22245-83-6), also known as 2-hydroxy-3-(trifluoromethyl)pyridine, is a trifluoromethyl substituted 2-hydroxypyridine. In catalytic reactions, the amide group of 2-pyridone binds to transition metals forming stable 5-/6-membred ring intermediates. Therefore, 3-(trifluoromethyl)-2-pyridone is extensively used as ligands in catalytic reaction such as directed C-H activation on meta-position. The trifluoromethyl substituent of 3-(trifluoromethyl)-2-pyridone tunes its metal-binding affinity and limits the reaction site for improving regioselectivity.

Many derivatives of 2-pyridone are bioactive such as Doravirine a non-nucleoside reverse transcriptase inhibitor for treatment of AIDS. An imidazoline derivative containing 2-pyridone is evaluated as neuropeptide-Y receptor Y5 antagonists and it displays significant inhibition of food intake for treatment of diet-induced obesity.

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