肝脏星形细胞是小叶内结缔组织细胞，呈现肌成纤维细胞样或脂肪细胞形态。他们参与肝脏细胞外基质的稳态，修复，再生，纤维化以有控制视黄醇的代谢，存储和释放。肝脏受伤后，肝脏星形细胞转化成肌成纤维细胞样，并且是纤维化的肝脏中 I 型胶原的主要来源。除了以上特征，已发现在疾病状态和肝内门静脉高压的发病过程中，肝星状细胞通过细胞收缩调节肝脏微循环[1,2]。星形细胞的增殖、迁移和趋化因子的表达参与了肝脏炎症和纤维化的发病过程。因此，星形细胞激活的分子调控在将来有助于治疗肝纤维化，并且能减少慢性肝病患者的发病率和死亡率。
Sciencell研究实验室的人肝星形细胞是从人肝脏组织中分离得到的，原代冻存，冰冻运输。每管细胞密度超过5×10^5/ml。人脐静脉平滑肌细胞经desmin 和α-actin免疫荧光鉴定。本细胞经检测不含HIV-1、HBV、HCV、支原体、细菌、酵母菌和真菌。如采用ScienCell 实验室特制的培养基，可保证此细胞15倍增增殖。? ?
推荐培养基：星形细胞培养基?(SteCM, Cat. #5301)
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货号
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5300
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产地
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美国
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缩写
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HHSteC
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规格
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5 x 10^5 /1ml
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用途
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科研
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储存
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液氮
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运输
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干冰
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关键字
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人肝星形细胞 HHSteC 人肝星形细胞 HHSteC 人肝星形细胞 HHSteC 人肝星形细胞 HHSteC 人肝星形细胞 HHSteC 人肝星形细胞 HHSteC
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公司简介
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合肥星肽生物科技有限公司作为专业的ScienCell中国代理商，专业经营实验室科研用原代细胞、原代细胞专用培养基、原代细胞无血清培养基、干细胞、干细胞培养基、干细胞无血清培养基的研究和开发。合肥星肽生物科技有限公司始终致力于为客户提供可靠的研究材料以及方便快捷的服务，对购买项目的前期资料提供,中期合同保证,后期货物跟踪到 *终售后的确保项目准确到位，都有相关专业人士进行维护,确保您在合肥合肥星肽生物科技有限公司公司获得***服务！
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联系方式
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何经理，合肥星肽生物科技有限公司，Tel： 400-8702-898，
E-mail：info@qingbio.com http://www.qingbio.com QQ:514713116
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1.) Wagner I,?Materne EM,?Brincker S,?S??bier U,?Fr?drich C,?Busek M,?Sonntag F,?Sakharov DA,?Trushkin EV,?Tonevitsky AG,?Lauster R,?Marx U. (2013) "A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture."?Lab Chip. doi: 10.1039/c3lc50234a
2.) Yamana D, Shimizu T, Fan Y, Miura T, Nanashima N, Yamada T, Hakamada K, Tsuchida S. (2011) "Decrease of hepatic stellate cells in rats with enhanced sensitivity to clofibrate-induced hepatocarcinogenesis."?Cancer Sci. 102: 735-41.
3.) Das A, Shergill U, Thakur L, Sinha S, Urrutia R, Mukhopadhyay D, Shah VH. (2010) "Ephrin B2/EphB4 pathway in hepatic stellate cells stimulates Erk-dependent VEGF production and sinusoidal endothelial cell recruitment."?Am J Physiol Gastrointest Liver Physiol. 298: G908-15.?
4.) Hozawa S, Nakamura T, Nakano M, Adachi M, Tanaka H, Takahashi Y, Tetsuya M, Miyata N, Soma H, Hibi T. (2008) "Induction of matrix metalloproteinase-1 gene transcription by tumour necrosis factor alpha via the p50/p50 homodimer of nuclear factor-kappa B in activated human hepatic stellate cells."?Liver Int. 28: 1418-25.?
5.) Mart?n-V?lchez S, Sanz-Cameno P, Rodr?guez-Mu?oz Y, Majano PL, Molina-Jim?nez F, L?pez-Cabrera M, Moreno-Otero R, Lara-Pezzi E. (2008) "The hepatitis B virus X protein induces paracrine activation of human hepatic stellate cells."?Hepatology. 47: 1872-83.
6.) Semela D, Das A, Langer D, Kang N, Leof E, Shah V. (2008) "Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function."Gastroenterology. 135: 671-9.
7.) Shimamura T, Fujisawa T, Husain SR, Kioi M, Nakajima A, Puri RK. (2008) "Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model."?J Immunol. 181: 4656-65.
8.) Che J, Chan ES, Cronstein BN. (2007) "Adenosine A2A receptor occupancy stimulates collagen expression by hepatic stellate cells via pathways involving protein kinase A, Src, and extracellular signal-regulated kinases 1/2 signaling CAS:cade or p38 mitogen-activated protein kinase signaling pathway."?Mol Pharmacol. 72: 1626-36.
9.) Perri RE, Langer DA, Chatterjee S, Gibbons SJ, Gadgil J, Cao S, Farrugia G, Shah VH. (2006) "Defects in cGMP-PKG pathway contribute to impaired NO-dependent responses in hepatic stellate cells upon activation."?Am J Physiol Gastrointest Liver Physiol. 290: G535-42.
10.) Brown KE, Broadhurst KA, Mathahs MM, Brunt EM, Schmidt WN. (2005) "Expression of HSP47, a collagen-specific chaperone, in normal and diseased human liver."?Lab Invest. 85: 789-97.
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