产品名称：Anti-CACNA1B (N type) /FITC抗体

Anti-CACNA1B (N type) /FITC抗体

产品编号YB10490R-FITC

英文名称Anti-CACNA1B (N type) /FITC

中文名称FITC标记的电压依赖型N型钙通道α1B抗体

别    名CAC1B_HUMAN; Voltage-dependent N-type calcium channel subunit alpha-1B; Brain calcium channel III; BIII; Calcium channel, L type, alpha-1 polypeptide isoform 5; Voltage-gated calcium channel subunit alpha Cav2.2; voltage-dependent N-type calcium channel subunit alpha-1B isoform 1; calcium channel, voltage-dependent, L type, alpha; 1B subunit; voltage-dependent N-type calcium channel subunit alpha-1B; calcium channel, N type; calcium channel, voltage-dependent, alpha 1B subunit, N type; calcium channel alpha12.2 subunit; Cav2.2 voltage-gated Ca2+ channel.

Anti-CACNA1B (N type) /FITC抗体

说 明 书100ul  

研究领域

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量257kDa

Anti-CACNA1B (N type) /FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human CACNA1B (N type)

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-CACNA1B (N type) /FITC抗体

产品介绍background:

The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].

Function:

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

Subunit:

Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit.Anti-CACNA1B (N type) /FITC抗体 In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with RIMS1 and RIMBP2.

Subcellular Location:

Membrane; Multi-pass membrane protein.

Tissue Specificity:

Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta.

Post-translational modifications:

Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK.

Similarity:

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily.

Contains 1 EF-hand domain.

Database links:

UniProtKB/Swiss-Prot: Q00975

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.