Anti-Phospho-Stat2 (Tyr690)/FITC抗体 Anti-Phospho-Stat2 (Tyr690)/FITC

Anti-Phospho-Stat2 (Tyr690)/FITC抗体

产品编号YB3428R-FITC

英文名称Anti-Phospho-Stat2 (Tyr690)/FITC

中文名称FITC标记的磷酸化信号转导和转录激活因子2抗体

别    名Stat2 (phospho-Tyr690); Stat2 (phospho Y690); Stat2 (phospho Tyr690); p-Stat2 (Tyr690); signal transducers and activators of transduction2; Homo sapiens interferon alpha induced transcriptional activator; interferon alpha induced transcriptional activator; ISGF3; P113; signal transducer and activator of transcription 2 113kD; STAT113; STAT2_HUMAN; p113.  

Anti-Phospho-Stat2 (Tyr690)/FITC抗体

说 明 书100ul  

产品类型磷酸化抗体

研究领域肿瘤  细胞生物  **学  细胞凋亡  转录调节因子  激酶和磷酸酶  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Dog, Horse,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量94kDa

Anti-Phospho-Stat2 (Tyr690)/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

*** 原KLH conjugated Synthesised phosphopeptide derived from human Stat2 around the phosphorylation site of Tyr690

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-Phospho-Stat2 (Tyr690)/FITC抗体

产品介绍background:

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

Function:

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Subunit:

Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein (By similarity). Can form a homodimer upon IFN-alpha induced phosphorylation. Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-466'. Interacts with IFNAR2. Interacts with dengue virus NS5; Anti-Phospho-Stat2 (Tyr690)/FITC抗体this interaction inhibits the phosphorylation of STAT2, and, when all viral proteins are present (polyprotein), targets STAT2 for degradation. Interacts with human cytomegalovirus/HHV-5 protein UL123; this interaction promotes viral growth.

Subcellular Location:

Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.

Post-translational modifications:

Tyrosine phosphorylated in response to IFN-alpha.

Similarity:

Belongs to the transcription factor STAT family.

Contains 1 SH2 domain.

Database links:

Entrez Gene: 6773 Human

Entrez Gene: 20847 Mouse

Entrez Gene: 288774 Rat

Omim: 600556 Human

SwissProt: P52630 Human

SwissProt: Q9WVL2 Mouse

Unigene: 530595 Human

Unigene: 293120 Mouse

Unigene: 471333 Mouse

Unigene: 24237 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

STAT-信号转导和转录激活因子蛋白家族是近年来发现的一类转录因子.通过JAK-STAT途径介导许多由细胞因子诱导的反应,参与细胞的信号转导和转录。